Homepage of Kyriakos Kachrimanis

Κυριάκος Καχριμάνης, καθηγητής Φαρμακευτικής
Τομέας Φαρμακευτικής Τεχνολογίας
Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
54124 Θεσσαλονίκη, Ελλάς
τηλ. +02310997666 email: kgk@pharm.auth.gr
Karagianni, A., Quodbach, J., Weingart, O., Tsiaxerli, A., Katsanou, V., Vasylyeva, V., Janiak, C., Kachrimanis, K. (2022) Structural and Energetic Aspects of Entacapone-Theophylline-Water Cocrystal. Solids 3(1), 66-92; DOI: https://doi.org/10.3390/solids3010006

Vardaka, E., Andreas, O., Nikolakakis, I., Kachrimanis, K. Development of agomelatine nanocomposite formulations by wet media milling (2021) European Journal of Pharmaceutical Sciences, 166, art. no. 105979, DOI: https://doi.org/10.1016/j.ejps.2021.105979 

Pešić, N., Dapčević, A., Ivković, B., Kachrimanis, K., Mitrić, M., Ibrić, S., Medarević, D. Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol (2021) International Journal of Pharmaceutics, 608, art. no. 121033, DOI: https://doi.org/10.1016/j.ijpharm.2021.121033 

Tsiaxerli, A., Karagianni, A., Ouranidis, A., Kachrimanis, K. Polyelectrolyte matrices in the modulation of intermolecular electrostatic interactions for amorphous solid dispersions: A comprehensive review (2021) Pharmaceutics, 13 (9), art. no. 1467, DOI: https://doi.org/10.3390/pharmaceutics13091467 

Ouranidis, A., Gkampelis, N., Markopoulou, C., Nikolakakis, I., Kachrimanis, K. Development of a nanocrystal formulation of a low melting point api following a quality by design approach (2021) Processes, 9 (6), art. no. 954, DOI: https://doi.org/10.3390/pr9060954 

Ouranidis, A., Gkampelis, N., Vardaka, E., Karagianni, A., Tsiptsios, D., Nikolakakis, I., Kachrimanis, K. Overcoming the solubility barrier of ibuprofen by the rational process design of a nanocrystal formulation (2020) Pharmaceutics, 12 (10), art. no. 969, pp. 1-32. DOI: https://doi.org/10.3390/pharmaceutics12100969 

Malamatari, M., Charisi, A., Malamataris, S., Kachrimanis, K., Nikolakakis, I. Spray drying for the preparation of nanoparticle-based drug formulations as dry powders for inhalation (2020) Processes, 8 (7), art. no. 788, DOI: https://doi.org/10.3390/pr8070788 

Medarević, D., Ibrić, S., Vardaka, E., Mitrić, M., Nikolakakis, I., Kachrimanis, K. Insight into the formation of glimepiride nanocrystals by wet media milling (2020) Pharmaceutics, 12 (1), art. no. 53, DOI: https://doi.org/10.3390/pharmaceutics12010053 

Medarević, D., Djuriš, J., Barmpalexis, P., Kachrimanis, K., Ibrić, S. Analytical and computational methods for the estimation of drug-polymer solubility and miscibility in solid dispersions development (2019) Pharmaceutics, 11 (8), art. no. 372, DOI: https://doi.org/10.3390/pharmaceutics11080372 

Barmpalexis, P., Vardaka, E., Moutafidis, I.-M., Kachrimanis, K. Amorphous agomelatine stabilization in the presence of pyrogenic silica: Molecular mobility and intermolecular interaction studies (2019) European Journal of Pharmaceutics and Biopharmaceutics, 139, pp. 291-300. DOI: https://doi.org/10.1016/j.ejpb.2019.04.015 

Barmpalexis, P., Karagianni, A., Katopodis, K., Vardaka, E., Kachrimanis, K. Molecular modelling and simulation of fusion-based amorphous drug dispersions in polymer/plasticizer blends (2019) European Journal of Pharmaceutical Sciences, 130, pp. 260-268. DOI: https://doi.org/10.1016/j.ejps.2019.02.004 

Barmpalexis, P., Karagianni, A., Nikolakakis, I., Kachrimanis, K. Preparation of pharmaceutical cocrystal formulations via melt mixing technique: A thermodynamic perspective (2018) European Journal of Pharmaceutics and Biopharmaceutics, 131, pp. 130-140. DOI: https://doi.org/10.1016/j.ejpb.2018.08.002 

Barmpalexis, P., Karagianni, A., Nikolakakis, I., Kachrimanis, K. Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy (2018) Journal of Pharmaceutical and Biomedical Analysis, 158, pp. 214-224. DOI: https://doi.org/10.1016/j.jpba.2018.06.004 

Karagianni, A., Kachrimanis, K., Nikolakakis, I. Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery (2018) Pharmaceutics, 10 (3), art. no. 98, DOI: https://doi.org/10.3390/pharmaceutics10030098 

Barmpalexis, P., Karagianni, A., Kachrimanis, K. Molecular simulations for amorphous drug formulation: Polymeric matrix properties relevant to hot-melt extrusion (2018) European Journal of Pharmaceutical Sciences, 119, pp. 259-267. DOI: https://doi.org/10.1016/j.ejps.2018.04.035 

Medarević, D., Djuriš, J., Ibrić, S., Mitrić, M., Kachrimanis, K. Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling (2018) International Journal of Pharmaceutics, 540 (1-2), pp. 150-161. DOI: https://doi.org/10.1016/j.ijpharm.2018.02.011 

Malamatari, M., Taylor, K.M.G., Malamataris, S., Douroumis, D., Kachrimanis, K. Pharmaceutical nanocrystals: production by wet milling and applications (2018) Drug Discovery Today, 23 (3), pp. 534-547. DOI: https://doi.org/10.1016/j.drudis.2018.01.016 

Karagianni, A., Malamatari, M., Kachrimanis, K. Pharmaceutical cocrystals: New solid phase modification approaches for the formulation of APIs (2018) Pharmaceutics, 10 (1), art. no. 18, DOI: https://doi.org/10.3390/pharmaceutics10010018 

Barmpalexis, P., Grypioti, A., Vardaka, E., Karagianni, A., Kachrimanis, K. Development of a Novel Amorphous Agomelatine Formulation With Improved Storage Stability and Enhanced Bioavailability (2018) Journal of Pharmaceutical Sciences, 107 (1), pp. 257-266. DOI: https://doi.org/10.1016/j.xphs.2017.09.017 

Toziopoulou, F., Malamatari, M., Nikolakakis, I., Kachrimanis, K. Production of aprepitant nanocrystals by wet media milling and subsequent solidification (2017) International Journal of Pharmaceutics, 533 (2), pp. 324-334. DOI: https://doi.org/10.1016/j.ijpharm.2017.02.065 

Malamatari, M., Somavarapu, S., Kachrimanis, K., Buckton, G., Taylor, K.M.G. Preparation of respirable nanoparticle agglomerates of the low melting and ductile drug ibuprofen: Impact of formulation parameters (2017) Powder Technology, 308, pp. 123-134. DOI: https://doi.org/10.1016/j.powtec.2016.12.007 

Nikolakakis, I., Kachrimanis, K. Crystallization kinetics of orthorhombic paracetamol from supercooled melts studied by non-isothermal DSC (2017) Drug Development and Industrial Pharmacy, 43 (2), pp. 257-263. DOI: https://doi.org/10.1080/03639045.2016.1236810 

Malamatari, M., Somavarapu, S., Kachrimanis, K., Bloxham, M., Taylor, K.M.G., Buckton, G. Preparation of theophylline inhalable microcomposite particles by wet milling and spray drying: The influence of mannitol as a co-milling agent (2016) International Journal of Pharmaceutics, 514 (1), pp. 200-211.  DOI: https://doi.org/10.1016/j.ijpharm.2016.06.032 

Medarević, D.P., Kachrimanis, K., Mitrić, M., Djuriš, J., Djurić, Z., Ibrić, S. Dissolution rate enhancement and physicochemical characterization of carbamazepine-poloxamer solid dispersions (2016) Pharmaceutical Development and Technology, 21 (3), pp. 268-276. DOI: https://doi.org/10.3109/10837450.2014.996899 

Medarević, D., Kachrimanis, K., Djurić, Z., Ibrić, S. Influence of hydrophilic polymers on the complexation of carbamazepine with hydroxypropyl-β-cyclodextrin (2015) European Journal of Pharmaceutical Sciences, 78, pp. 273-285. DOI: https://doi.org/10.1016/j.ejps.2015.08.001 

Djuris, J., Nikolakakis, I., Ibric, S., Djuric, Z., Kachrimanis, K. Preparation of carbamazepine-Soluplus® solid dispersions by hot-melt extrusion, and prediction of drug-polymer miscibility by thermodynamic model fitting (2013) European Journal of Pharmaceutics and Biopharmaceutics, 84 (1), pp. 228-237. DOI: https://doi.org/10.1016/j.ejpb.2012.12.018 

Kachrimanis, K., Griesser, U.J. Dehydration kinetics and crystal water dynamics of carbamazepine dihydrate (2012) Pharmaceutical Research, 29 (4), pp. 902-921. DOI: https://doi.org/10.1007/s11095-012-0698-4 

Kachrimanis, K., Fucke, K., Noisternig, M., Siebenhaar, B., Griesser, U.J. Effects of moisture and residual solvent on the phase stability of orthorhombic paracetamol (2008) Pharmaceutical Research, 25 (6), pp. 1440-1449. DOI: https://doi.org/10.1007/s11095-007-9529-4 

Kachrimanis, K., Braun, D.E., Griesser, U.J. Quantitative analysis of paracetamol polymorphs in powder mixtures by FT-Raman spectroscopy and PLS regression (2007) Journal of Pharmaceutical and Biomedical Analysis, 43 (2), pp. 407-412. DOI: https://doi.org/10.1016/j.jpba.2006.07.032 

Antikainen, O., Kachrimanis, K., Malamataris, S., Yliruusi, J., Sandler, N. Image analysis by pulse coupled neural networks (PCNN) - A novel approach in granule size characterization (2007) Journal of Pharmacy and Pharmacology, 59 (1), pp. 51-57. DOI: https://doi.org/10.1211/jpp.59.1.0007 

Kachrimanis, K., Noisternig, M.F., Griesser, U.J., Malamataris, S. Dynamic moisture sorption and desorption of standard and silicified microcrystalline cellulose (2006) European Journal of Pharmaceutics and Biopharmaceutics, 64 (3), pp. 307-315. DOI: https://doi.org/10.1016/j.ejpb.2006.05.019
Ich habe nichts dagegen wenn Sie langsam denken, Herr Doktor, aber ich habe etwas dagegen wenn Sie rascher publizieren als denken.
- Wolfgang Pauli