Dr Paraskevas D. Tzanavaras
Lecturer of Analytical Chemistry

Aristotle University of Thessaloniki
Department of Chemistry
Laboratory of Analytical Chemistry


PUBLICATIONS IN INTERNATIONAL REFEREED JOURNALS 

WITH IMPACT FACTOR

 

75) “Chromatographic behavior of the biologically active proline derivative captopril on particulate, monolithic and core-shell narrow bore columns”
C.K. Zacharis, T.D. Karakosta, P.D. Tzanavaras*, P. Rigas and D.G. Themelis
Anal. Meth., 4 (2012) 4373

74) “High-throughput determination of quinine in beverages and soft drinks based on zone-fluidics coupled to monolithic liquid chromatography”
P.D. Tzanavaras*, C.K. Zacharis, T.D. Karakosta, A. Zotou and D.G. Themelis
Anal. Lett., in press.

73) “Isocratic liquid chromatographic determination of three paraben preservatives in hygiene wipes using a reversed phase core-shell narrow-bore column”
P.D. Tzanavaras*, T.D. Karakosta, P.G. Rigas, D.G. Themelis and A. Zotou
Centr. Eur. J. Chem., 10 (2012) 1459

72) “On-line micro-volume introduction system developed for lower density than water extraction solvent and dispersive liquid-liquid microextraction coupled with flame atomic absorption spectrometry”
A. Anthemidis*, C. Mitani, P. Balkatzopoulou and P.D. Tzanavaras
Anal. Chim. Acta, 733 (2012) 34

71) “Automated determination of total captopril in urine by liquid chromatography with post-column derivatization coupled to on-line solid phase extraction in a sequential injection manifold”
T.D. Karakosta, P.D. Tzanavaras and D.G. Themelis*
Talanta, 88 (2012) 561

70) “Automated determination of hydrogen peroxide at the micro-molar level in rainwater and snow using a stopped-flow approach in a hybrid sequential injection/flow injection manifold”
P.D. Tzanavaras* and E. Boulimari
Anal. Lett., 45 (2012) 1086

69) “On-line cleavage of disulfide bonds by soluble and immobilized tris-(2-carboxyethyl)phosphine using sequential injection analysis”
P.D. Tzanavaras*, C. Mitani, A. Anthemidis and D.G. Themelis
Talanta, 96 (2012) 21

68) “A green HPLC method for the determination of N-acetylcysteine using post-column derivatization with methyl-propiolate”
P.D. Tzanavaras*
Instrum. Sci. & Technol., 40 (2012) 150

67) “Automated derivatization of pharmaceutically active thiols under flow conditions using an o-phthalaldehyde / glycine fluorogenic system and sequential injection analysis.”
T.D. Karakosta and P.D. Tzanavaras*
Anal. Lett., 44 (2011) 2530

66) “Automated pre-column derivatization of thiolic fruit-antibrowning agents by sequential injection coupled to high performance liquid chromatography using a monolithic stationary phase and an in-loop stopped-flow approach”
T.D. Karakosta, P.D. Tzanavaras and D.G. Themelis*
J. Sep. Sci., 34 (2011) 2240

65) “Development and validation of an ultra-fast liquid chromatographic method for the quality control of famotidine formulations using a short monolithic stationary phase.”
P.D. Tzanavaras*
Central Eur. J. Chem., 9 (2011) 446

64) “Development and validation of a rapid HPLC method for the determination of five banned fat-soluble colorants in spices using a narrow-bore monolithic column.”
C.K. Zacharis*, F.S. Kika, P.D. Tzanavaras, P. Rigas and E.R. Kyranas
Talanta, 84 (2011) 480
   
63) “Ethyl propiolate as a post-column derivatization reagent for thiols: development of a green liquid chromatographic method for the determination of glutathione in vegetables.”
C.K. Zacharis, P.D. Tzanavaras* and A. Zotou
Anal. Chim. Acta, 690 (2011) 122

62) “HPLC separation of nimesulide and five impurities using a narrow-bore monolithic column: application to photo-degradation studies.”
C.K. Zacharis and P.D. Tzanavaras*
Chromatographia, 73 (2011) 347

61) “Automated tagging of pharmaceutically active thiols under flow conditions using monobromobimane.”
P.D. Tzanavaras* and T.D. Karakosta
J. Pharm. Biomed. Anal., 54 (2011) 882

60) “NBD-Cl as a post-column reagent for primary and secondary amines after separation by ion-exchange chromatography.”
C.K. Zacharis, P.D. Tzanavaras, P.N. Mouroutis and P. Rigas*
Anal. Lett., 44 (2011) 1821

59) “Automated determination of Captopril by flow and sequential injection analysis: a review”
P.D. Tzanavaras*
Anal. Lett., 44 (2011) 560

58) “Derivatization of thiols under flow conditions using two commercially available propiolate esters.”
P.D. Tzanavaras*, A. Tsiomlektsis and C.K. Zacharis
 J. Pharm. Biomed. Anal., 53 (2010) 790

57) “LC-determination of five paraben preservatives in saliva and toothpaste samples using UV detection and a short monolithic column.”
A. Zotou*, I. Sakla and P.D. Tzanavaras
J. Pharm. Biomed. Anal., 53 (2010) 785

56) “Solvent-based de-emulsification dispersive liquid-liquid microextraction combined with gas chromatography – mass spectrometry for determination of trace organochlorine pesticides in environmental water samples.”
C.K. Zacharis*, P.D. Tzanavaras, C. Roubos, K. Dima
J. Chromatogr. A, 1217 (2010) 5896

55) “On-line derivatization of N-acetylcysteine using ethyl-propiolate as a novel advantageous reagent and sequential injection analysis”.
P.D. Tzanavaras*, C.K. Zacharis and D.G. Themelis
Anal. Lett., 43 (2010) 1889

54) “High throughput automated determination of glutathione based on the formation of a UV-absorbing thioacrylate derivative” (Invited article)
C.K. Zacharis and P.D. Tzanavaras*
Comb. Chem. & High Through. Screen., 13 (2010) 461

53) “Recent advances in the analysis of organic impurities of active pharmaceutical ingredients and formulations: a review”
P.D. Tzanavaras*
Curr. Org. Chem., 14 (2010) 2348

52) “Rapid determination of methylxanthines in real samples by high performance liquid chromatography using the new FastGradientŪ narrow-bore monolithic column.” 
P.D. Tzanavaras*, C.K. Zacharis and D.G. Themelis
Talanta, 81 (2010) 1494

51) “Generic automated fluorimetric assay for the quality control of gamma aminobutyric acid-analogue anti-epileptic drugs using sequential injection analysis”.
D.G. Themelis*, P.D. Tzanavaras and E.A. Boulimari
Anal. Lett., 43 (2010) 905

50) “Ethyl-propiolate as a novel and promising analytical reagent for the derivatization of thiols: study of the reaction under flow conditions.”
C.K. Zacharis*, P.D. Tzanavaras and D.G. Themelis
J. Pharm. Biomed. Anal., 50 (2009) 384

49) “Automated zone-sampling dilution by coupling sequential injection analysis to high-throughput HPLC for the direct determination of gemfibrozil.”
P.D. Tzanavaras*, D.G. Themelis and P. Rigas
J. Sep. Sci., 32 (2009) 2819

48) “Automated sample preparation coupled to sequential injection chromatography: on-line filtration and dilution protocols prior to separation.”
C.K. Zacharis, A. Verdoukas, P.D. Tzanavaras* and D.G. Themelis
J. Pharm. Biomed. Anal., 49 (2009) 726

47) “Development and validation of a micellar electrokinetic chromatography method for the purity control of nimesulide pharmaceuticals.”
C.K. Zacharis, P.D. Tzanavaras*, M. Notou, A. Zotou and D.G. Themelis
J. Pharm. Biomed. Anal., 49 (2009) 201

46) “Selective determination of cyanides by gas diffusion – stopped flow – sequential injection analysis and an on-line standard addition approach.”
D.G. Themelis*, S. Karastogianni and P.D. Tzanavaras
Anal. Chim. Acta, 632 (2009) 93

45) “Hybrid sequential injection – flow injection manifold for the spectrophotometric determination of total sulfite in wines using o-pthalaldehyde and gas-diffusion.”
P.D. Tzanavaras, E. Thiakouli and D.G. Themelis*
Talanta, 77 (2009) 1614

44) “Amperometric determination of cyanides at the low ppb level by automated preconcentration based on gas diffusion coupled to sequential injection analysis.”
C.K. Zacharis*, P.D. Tzanavaras, A.N. Voulgaropoulos* and B. Karlberg
Talanta, 77 (2009) 1620

43) “Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution.”
P.D. Tzanavaras*, C.K. Zacharis and P. Rigas
J. Pharm. Biomed. Anal., 48 (2008) 1254

42) “Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological material: A review of analytical methods.”
C.K. Zacharis* and P.D. Tzanavaras
J. Pharm. Biomed. Anal., 48 (2008) 483

41) “Extraction of acyclovir from pharmaceutical creams prior to HPLC assay analysis. Optimization and validation of pre-treatment protocols.” (invited article)
P.D. Tzanavaras and C.K. Zacharis*
Central Eur. J. Chem., 6 (2008) 140

40) “Optimization and validation of a dissolution test for selegiline hydrochloride tablets by a novel rapid HPLC assay using a monolithic stationary phase.”
P.D. Tzanavaras*, D.G. Themelis, A. Zotou, J. Stratis and B. Karlberg
J. Pharm. Biomed. Anal., 46 (2008) 670

39) “Sequential-injection analysis: a useful tool for clinical and biochemical analysis.” (invited article)
A. Economou*, P.D. Tzanavaras and D.G. Themelis
Curr. Pharm. Anal., 3 (2007) 249

38) “Review of recent applications of flow injection spectrophotometry to pharmaceutical analysis.”
P.D. Tzanavaras* and D.G. Themelis
Anal. Chim. Acta, 588 (2007) 1

37) “Automated determination of flutamide by a validated flow-injection method. Application to dissolution studies of pharmaceutical tablets.”
P.D. Tzanavaras* and D.G. Themelis
J. Pharm. Biomed. Anal., 43 (2007) 1820

36) “Highly selective flow injection spectrophotometric determination of gold based on its catalytic effect on the oxidation of variamine blue by potassium iodate in aqueous N,N-dimethylformamide medium”
D.G. Themelis*, A.V. Trellopoulos, P.D. Tzanavaras and M. Sofoniou
Talanta, 72 (2007) 277
 
35) “Review on analytical methods for the determination of chlorine dioxide” (invited article)
P.D. Tzanavaras*, D.G. Themelis* and F.S. Kika
Central Eur. J. Chem., 5 (2007) 1

34) “Rapid HPLC assay of acyclovir and its major impurity guanine in raw materials and pharmaceutical creams using a monolithic column and a flow gradient approach”
P.D. Tzanavaras* and D.G. Themelis
J. Pharm. Biomed. Anal., 43 (2007) 1526

33) “Validated high-throughput HPLC assay for nimesulide using a short monolithic column”
P.D. Tzanavaras* and D.G. Themelis
J. Pharm. Biomed. Anal., 43 (2007) 1483
 
32) “Development and validation of a high-throughput HPLC assay for the determination of caffeine in food samples using a monolithic column”
P.D. Tzanavaras* and D.G. Themelis
Anal. Chim. Acta, 581 (2007) 89

31) “Optimization and validation of a dissolution test for famotidine tablets using flow injection analysis”
P.D. Tzanavaras*, A. Verdoukas and T. Balloma
J. Pharm. Biomed. Anal., 41 (2006) 437

30) “Sequential Injection Analysis : Principles, Construction of a SIA Analyzer and Demonstration by a Simple Experiment”
A. Economou*, P.D. Tzanavaras and D.G. Themelis
J. Chem. Educ., 82 (2005) 1820

29) “Development and validation of a flow injection assay for the dissolution studies of the anti-depressant drug venlafaxine.”
P.D. Tzanavaras*, A. Verdoukas and D.G. Themelis
Anal. Sci., 21 (2005) 1515

28) “Validated flow injection spectrophotometric assay for the quality and stability control of gemfibrozil tablets.”
P.D. Tzanavaras* and D.G. Themelis
Anal. Lett., 38 (2005) 2165

27) “Assay of the synthetic estrogen fosfestrol in pharmaceutical formulations using capillary electrophoresis.”
D.G. Themelis*, A.V. Trelopoulos, P.D. Tzanavaras and B. Karlberg
J. Pharm. Biomed. Anal., 39 (2005) 559

26) “Normal spectrophotometric and stopped-flow spectrofluorimetric sequential injection methods for the determination of alendronic acid, an anti-osteoporosis amino-bisphosphonate drug.” 
P.D. Tzanavaras, C.K. Zacharis, G. Theodoridis*, Ε.Α. Kalaitzantonakis and A. Voulgaropoulos
Anal. Chim. Acta, 547 (2005) 98

25) “Determination of orthophosphate in urine by sequential injection analysis with on-line dilution and photometric detection.”
D.G. Themelis*, A. Economou, A. Tsiomlektsis and P.D. Tzanavaras
Anal. Biochem., 330 (2004) 193

24) “Rapid spectrofluorimetric determination of lisinopril in pharmaceutical tablets using sequential injection analysis.”
C.K. Zacharis, P.D. Tzanavaras, D.G. Themelis*, G. Theodoridis, A. Economou, P. Rigas
Anal. Bioanal. Chem., 379 (2004) 759
 
23) “Determination of boron in water and pharmaceuticals by sequential injection analysis and fluorimetric detection.”
A. Economou*, D.G. Themelis, H. Bikou, P.D. Tzanavaras and P.G. Rigas
Anal. Chim. Acta, 510 (2004) 219
 
22) “Automated sample preparation based on the sequential injection principle. Solid – phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography.”
G. Theodoridis*, C.K. Zacharis, P.D. Tzanavaras, D.G. Themelis and A. Economou
J. Chromatogr. A, 1030 (2004) 69

21) “Determination of carbimazole and methimazole in pharmaceuticals by flow injection with chemiluminescence detection based on the inhibition of the Cu(II)-catalyzed luminol-hydrogen peroxide reaction.”
A. Economou*, P.D. Tzanavaras, M. Notou and D.G. Themelis.
Anal. Chim. Acta, 505 (2004) 129

20) “Sequential injection method for the direct spectrophotometric determination of bismuth in pharmaceutical products.”
P.D. Tzanavaras, D.G. Themelis* and A. Economou.
Anal. Chim. Acta, 505 (2004) 167
 
19) “Novel flow-injection spectrophotometric determination of fosinopril using UV-assisted digestion and an orthophosphates calibration graph.”
P.D. Tzanavaras and D.G. Themelis*.
Anal. Chim. Acta, 481 (2003) 321

18) “Flow injection manifold for the rapid spectrophotometric determination of fosfestrol, following on-line thermal induced digestion by peroxodisulfate ion and using an orthophosphate calibration graph.”
P.D. Tzanavaras and D.G. Themelis*
Talanta, 59 (2003) 207

17) “Flow and sequential injection manifolds for the spectrophotometric determination of captopril based on its oxidation by Fe(III).”
P.D. Tzanavaras, D.G. Themelis*, A. Economou and G. Theodoridis.
Μicrochim. Acta, 142 (2003) 55

16) “Sensitive determination of captopril by flow injection analysis with chemiluminescence detection based on the enhancement of the luminol reaction.”
A. Economou*, D.G. Themelis, G. Theodoridis and P.D. Tzanavaras.
Anal. Chim. Acta, 463 (2002) 249

15) “Rapid spectrophotometric determination of fosfestrol following on-line hydrolysis by alkaline phosphatase using flow injection and chasing zones.”
P.D. Tzanavaras, D.G. Themelis* and B. Karlberg.
Anal. Chim. Acta, 462 (2002) 119

14) “Flow-injection spectrophotometric determination of the antibiotic fosfomycin in pharmaceutical products and urine samples after on-line thermal induced digestion.”
P.D. Tzanavaras and D.G. Themelis*.
Anal. Biochem., 304 (2002) 244

13) “Reversed flow-injection manifold for the spectrophotometric determination of captopril based on its inhibitory effect on the Co(II)- 2,2΄-dipyridyl-2-pyridylhydrazone complex formation.”
P.D. Tzanavaras, D.G. Themelis*, A. Economou and G. Theodoridis.
Talanta, 57 (2002) 575

12) “Simultaneous flow-injection determination of fluoride, monofluorophosphate and orthophosphate ions using alkaline phosphatase immobilized on a cellulose nitrate membrane and an open-circulation approach.”
 P.D. Tzanavaras and D.G. Themelis*.
Anal. Chim. Acta, 467 (2002) 83

11) “Solvent extraction flow-injection manifold for the simultaneous spectrophotometric determination of free cyanide and thiocyanate ions based upon on-line masking of cyanides by formaldehyde.” (Part of PhD Thesis)
D.G. Themelis* and P.D. Tzanavaras.
Anal. Chim. Acta, 452 (2002) 295

10) “Direct and selective flow-injection method for the simultaneous spectrophotometric determination of calcium and magnesium in red and white wines using on-line dilution based on “zone sampling”.”
 D.G. Themelis*, P.D. Tzanavaras, A. V. Trellopoulos and M.C. Sofoniou.
 J. Agric. Food Chem., 49 (2001) 5152

9) “Rapid flow-injection spectrophotometric determination of monofluorophosphates in toothpastes after on-line hydrolysis by alkaline phosphatase immobilized on a cellulose nitrate membrane.” (Part of PhD thesis)
P.D. Tzanavaras and D.G. Themelis*.
Analyst, 126 (2001) 1608

8) “Flow injection manifold for the simultaneous spectrophotometric determination of Fe(II) and Fe(III) using 2,2΄-dipyridyl-2-pyridylhydrazone and a single-line double injection approach.”
D.G. Themelis*, P.D. Tzanavaras, F.S. Kika and M.C. Sofoniou.
Fresenius’ J. Anal. Chem., 371 (2001) 364

7) “On-line dilution flow injection manifold for the selective spectrophotometric determination of ascorbic acid based on the iron(II)- 2, 2-dipyridyl-2-pyridyl hydrazone complex formation.”
D.G. Themelis*, P.D. Tzanavaras and F.S. Kika.
Talanta, 55 (2001) 127

6) “Simple, rapid reagent-injection spectrophotometric determination of fluorides in pharmaceutical formulations.”
D.G. Themelis*, P.D. Tzanavaras and H.D. Tzanavaras.
J. Pharm. Biomed. Anal., 25 (2001) 971

5) “Flow injection manifold for the direct spectrophotometric determination of bismuth in pharmaceutical products using methylthymol blue as colour forming agent.”
D.G. Themelis*, P.D. Tzanavaras and J.K. Papadimitriou.
Analyst, 126 (2001) 247

4) “Simultaneous spectrophotometric determination of fluoride and monofluorophosphate ions in toothpastes using a reagent-injection manifold.” (Part of PhD Thesis)
D.G. Themelis* and P.D. Tzanavaras.
Anal. Chim. Acta, 429 (2001) 113

3) “Reagent-injection spectrophotometric determination of citric acid in beverages and pharmaceutical formulations based on its inhibitory effect on the iron(III) catalytic oxidation of 2, 4-diaminophenol by hydrogen peroxide.” (Part of PhD Thesis)
D.G. Themelis* and P.D. Tzanavaras.
Anal. Chim. Acta, 428 (2001) 23

2) “Normal and differential demasking flow injection manifold for the direct spectrophotometric deterimnation of zinc(II) in biological materials and pharmaceutical formulations.”
D.G. Themelis*, P.D. Tzanavaras, A.A. Liakou, H.D. Tzanavaras and J.K. Papadimitriou.
Analyst, 125 (2000) 2106

1) “Direct, selective flow injection spectrophotometric determination of calcium in wines using methylthymol blue and an on-line cascade dilution system.”
D.G. Themelis*, P.D. Tzanavaras, A.N. Anthemidis and J. Stratis.
Anal. Chim. Acta, 402 (1999) 259



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